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Foundation to Fight H-ABC, University of Massachusetts Medical School and Yale University Initiate Gene Therapy Study Targeting Cure for Rare Disease

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ROCKVILLE, Md., Oct. 13, 2020 /PRNewswire/ — Foundation to Fight H-ABC, a non-profit organization dedicated to increasing awareness and driving development of a cure for the degenerative children’s disease, H-ABC, today announced a sponsored research agreement with the University of Massachusetts Medical School and Yale University to advance a targeted gene therapy for H-ABC.

“We have high hopes to quickly prove efficacy with this approach to move research forward and find a permanent cure for this devastating disease,” said Michele Sloan, Co-Founder, Foundation to Fight H-ABC.

H-ABC (hypomyelination with atrophy of the basal ganglia and cerebellum) belongs to a group of conditions called leukodystrophies, diseases that affect the white matter of the brain. These diseases disrupt the growth or maintenance of the myelin sheath, a protective layer that insulates nerve cells and allows for the transmission of messages between cells.

Caused by a mutation in the TUBB4A gene, H-ABC is a rare genetic disorder that affects certain parts of the brain—specifically the basal ganglia and the cerebellum, which control movement. H-ABC targets these important structures, reducing both their size and function. As a result, children who suffer from H-ABC often experience motor problems, cannot walk, talk, or sit on their own. Currently, there is no known cure for this disabling and life-threatening condition.

The teams of Dr. Guangping Gao (University of Massachusetts Medical School) and Dr. Karel Liem (Yale School of Medicine) will combine extensive expertise in the fields of Adeno-associated virus (AAV), a platform for gene delivery for the treatment of a variety of human diseases and H-ABC disease models, to develop AAV vectors to silence or outcompete the mutated TUBB4A gene.

“To date, AAV-based gene delivery system is the vector of choice for in vivo gene therapy of many currently untreatable rare diseases including H-ABC,” said Guangping Gao,

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Marian University gets $24M gift for engineering school

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INDIANAPOLIS (AP) — Marian University’s plans to open an engineering school have gotten a $24 million boost from a family which owns a company that makes custom, die-cut components for several industries.

The Indianapolis school announced the gift from the Witchger family last week. Officials said the university was now halfway to its $50 million fundraising goal for the engineering school, following more than $1 million that’s been raised from several other donors.

The planned E.S. Witchger School of Engineering will be named for the Witchger family’s patriarch. The family owns and operates Indianapolis-based Marian Inc., which supplies parts for the medical, electronics and automotive industries.

Money raised to date will go toward start-up costs, including facilities and equipment, endowed scholarships, endowed faculty positions, curriculum design and student recruitment, the Indianapolis Business Journal reported.

The university expects the school’s first class will be welcomed in fall 2022. After graduating its first class, the university can seek approval from the Accreditation Board for Engineering and Technology.

The school’s degrees will concentrate in electrical and computer engineering, mechanical engineering and chemical engineering.

School President Daniel J. Elsener said opening its own engineering school will allow degree completion to be more efficient.

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Schar School of Policy and Government at George Mason University

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Schar School of Policy and Government at George Mason University

“Ultimately, I wanted to get my Master’s in International Security, focusing on conflict resolution, threat analysis, and intelligence. The thing that sets the school apart are the professors. They are at the forefront of their fields.”

—Becca Cooper, Master’s in International Security student

Proximity to the nation’s capital is a considerable advantage for those dreaming of a career in politics, government, and public service, and few schools are closer to the policy- and decision-makers of Washington, D.C. than the Schar School of Policy and Government at George Mason University.

Location to future careers and important internships is just the beginning of the numerous advantages an education at the Schar School affords. With 22 undergraduate and graduate programs, part-time and full-time options, and dedicated career services advisors, the Arlington, Va.-based Schar School prepares graduates for important positions in key agencies across a wide spectrum of specialties.

The Schar School was named No. 2 in the country in 2019 by U.S. News & World Report for its security studies programs. If you dream of a career in international security, homeland security, emergency management, or other subjects that tackle “wicked problems” around the world, the Schar School has top-rated academic programs to help you achieve your goals.

Schar School of Policy and Government top-ranked programs:

Bachelor of Arts in Government and International Politics

Bachelor of Science in Public Administration

Graduate Certificate in Biodefense

Graduate Certificate in Emergency Management and Homeland Security

Graduate Certificate in Global Health and Security

Graduate Certificate in Illicit Trade Analysis

Graduate Certificate in National Security and Public Policy

Graduate Certificate in Nonprofit Management

Graduate Certificate in Public Management

Graduate Certificate in Science, Technology, and Security

Graduate Certificate in Strategic Trade

Graduate Certificate in Terrorism and Homeland Security

Master’s in

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Ohio state school board has 6 of 11 elected seats up for grabs

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Catherine Candisky
 
| The Columbus Dispatch

Voters are electing six members of the state Board of Education this year, including three representing the central Ohio area.

The half-dozen seats are among the 11 elected positions on the board. Another eight members are appointed by the governor.

The 19-member panel creates policy and makes recommendations for K-12 education, and hires the state superintendent.

More: Election 2020: The Columbus Dispatch Voter Guide

While members are elected in nonpartisan races, the board has been political at times. Most recently, the board sparred over a resolution ultimately approved 12-5 in July condemning hate speech and racism in schools, directing the Department of Education to review curriculum models and tests for racial bias, and requiring bias training for employees.

The resolution followed the death of George Floyd, an unarmed Black man killed while in the custody of Minneapolis police, triggering protests across the nation. Conservatives on the board said the resolution was a rush to judgment and questioned the extent of racism in schools.

In central Ohio’s 6th district, incumbent Antoinette Miranda of Columbus is seeking a second four-year term against challenger Alice Nicks of Galena. The district covers most of Franklin County and all of Delaware and Knox counties.

Miranda is a professor of school psychology and interim chair of the Department of Teaching and Learning at Ohio State University. She has more than 35 years of experience in K-12 and post-secondary education, including six years as a school psychologist.

Miranda said her priorities on the board include improving state report cards for schools and districts to make them more understandable for parents, educators and stakeholders and better reflect progress in schools. She also wants to advocate for districts as lawmakers tackle school-funding issues.

“The board doesn’t really vote on state funding, but it

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The George Washington University Law School

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Join a long tradition of excellence.

The George Washington University Law School
Washington, D.C.

As D.C.’s first law school, the George Washington University Law School has set the standard for legal education for more than 150 years. GW Law has an impressive, longstanding record of educating forward-thinking leaders. For example, by 1895, our graduates had already written the patents for Bell’s telephone, Mergenthaler’s linotype machine, and Eastman’s roll film camera. We continue to set the curve today, with a robust curriculum offering more than 275 elective courses designed to give students both a broad and in-depth legal education.

Our world-renowned faculty is regularly featured in print and in the media for outlets such as The New York Times, The Wall Street Journal, MSNBC, and CNN. Our faculty also has been cited as having the second-most downloaded scholarship on the Social Science Research Network (SSRN) law school list. Our faculty members are experts who have written the leading textbooks in their fields and testified before Congress, but their primary commitment is to prepare the next generation of lawyers to meet the challenges of our ever-evolving world. In addition, our location in the heart of Washington, D.C., has allowed us to build a superb adjunct faculty of distinguished practitioners who are top lawyers at law firms, at government agencies, and on Capitol Hill. We’re the only law school where a sitting Supreme Court justice teaches a regular course.

Along with offering a robust curriculum, GW Law emphasizes helping students gain practical skills and professional knowledge to help build fulfilling careers. Our Fundamentals of Lawyering course helps students master the core knowledge provided by traditional first-year legal research and writing courses, along with the client problem-solving, creative thinking, and sound judgment that law firms have told us they desire in first-year associates.

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