College football odds, picks, predictions for Week 6, 2020: Proven model backing Florida, Clemson

Clemson hasn’t lost to an ACC opponent since Syracuse in October of 2017. The top-ranked Tigers will look to keep that amazing streak alive as they take on No. 7 Miami (FL) at 7:30 p.m. ET on Saturday. The Week 6 college football odds from William Hill give Clemson a 14-point edge at home. Elsewhere in the ACC, No. 8 North Carolina is a 5.5-point favorite in the latest college football lines as the Tar Heels host No. 19 Virginia Tech in another top-20 clash.

Which ACC teams have value in the college football spreads this week? And which teams from the SEC, Big 12 and every other conference in action should you back in your college football bets? Before making any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,200 for $100 players on its top-rated college football picks against the spread. It is a sizzling 20-3 on top-rated picks through five weeks of the 2020 college football season, returning over $1,300 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 6 from William Hill and locked in picks for every FBS matchup. Head to SportsLine to see every pick.

Top Week 6 college football predictions 

One of the top Week 6 college football picks the model is recommending: No. 4 Florida (-6.5 at William Hill) wins and covers on the road against No. 21 Texas A&M in a noon ET kickoff on Saturday. The Gators rank fourth nationally in scoring offense with 44.5 points per game as they’ve rolled to a 2-0 start with wins over South Carolina and Ole Miss. The Aggies, meanwhile, are 1-1 and haven’t covered a spread this season. 

The model is projecting Florida quarterback Kyle Trask to throw for almost 300 yards, while tight end Kyle Pitts records 80 yards of receiving and a score, as the Gators win by double digits and cover in almost 60 percent of simulations.

Another one of the top Week 6 college football predictions from the model: No. 1 Clemson (-14) covers the spread at home against No. 7 Miami in a massive ACC showdown. The Hurricanes are coming off a dominant 52-10 victory over Florida State in their last outing. Clemson, meanwhile, cruised to a 41-23 victory over Virginia last Saturday. Quarterback Trevor Lawrence put on a show against the Cavaliers, completing 25-of-38 pass attempts for 329 yards and three touchdowns. Running back Travis Etienne also had a strong showing last Saturday, recording 187 all-purpose yards and two touchdowns. 

Miami, meanwhile, enters Saturday’s showdown with one of the most potent offenses in college football, averaging 43.3 points per game. However, Miami’s defense showed vulnerability in its win over Louisville earlier this season, giving up 516 yards against the Cardinals. SportsLine’s model says Lawrence throws for over 250 yards and two touchdowns, while Etienne records well over 100 all-purpose yards and a score against the Hurricanes, resulting in Clemson covering the spread in nearly 60 percent of simulations. 

How to make Week 6 college football picks 

The model has also made the call on who wins and covers every other FBS game in Week 6, and it is also predicting an upset in one of the week’s biggest games. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 6? And which underdog will pull off a shocking upset? Check out the latest Week 6 college football odds below for some of the week’s most notable games, and then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $4,200 in profit over the past four-plus seasons, and find out.

Week 6 college football odds (via William Hill)

Tulane at Houston (-6.5)
Louisville at Georgia Tech (+4)
Virginia Tech at North Carolina (-5.5)
Texas at Oklahoma (-2.5)
Florida at Texas A&M (+6.5)
South Carolina at Vanderbilt (+12)
Duke at Syracuse (+1.5)
Tennessee at Georgia (-14)
Texas Tech at Iowa State (-12.5)
Kansas State at TCU (-9)
Pittsburgh at Boston College (+4.5)
Arkansas at Auburn (-14)
Alabama at Ole Miss (+24)
Mississippi State at Kentucky (-3)
Miami (FL) at Clemson (-14)
Missouri at LSU (-20.5)

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